Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SORD | Q00796 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163279 | 0.84 | MAPT (0.48) | ALDH1A1KDM4ETDP1MAPK1NPC1 | |
| SCHEMBL8558421 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4ETDP1DRD4DRD2 | |
| SCHEMBL8170319 | 0.78 | MAPT (0.52) | ALDH1A1KDM4EMAPK1TSHRNPC1 | |
| SCHEMBL8170423 | 0.76 | FAAH (0.61) | ALDH1A1MAPK1NPC1MAPTHTT | |
| SCHEMBL8169372 | 0.75 | HTT (0.49) | ALDH1A1KDM4ECYP3A4MAPK1TSHR | |
| SCHEMBL12858870 | 0.74 | ALDH1A1 (0.62) | ALDH1A1KDM4ETDP1DRD4DRD2 | |
| SCHEMBL30936089 | 0.74 | ALDH1A1 (0.62) | ALDH1A1KDM4ETDP1DRD4DRD2 | |
| SCHEMBL8111511 | 0.74 | HTT (0.77) | ALDH1A1KDM4ETDP1DRD4DRD2 | |
| SCHEMBL15190465 | 0.73 | MEN1 (0.41) | ALDH1A1KDM4EMAPK1NPC1MAPT | |
| SCHEMBL13711971 | 0.73 | KCNH2 (0.71) | ALDH1A1DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060472-A | Thiadiazole compounds useful as inhibitors of H+ /K+ atpase | APOTEX INC. (CA) | 2000-05-09 | — | — | US | claimed |
| WO-1999051584-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF H+/K+ ATPASE | APOTEX INC. (CA) | 1999-10-14 | — | — | WO | claimed |