SCHEMBL8173282

SCHEMBL8173282

CCCn1nc(C(=O)NC2CCCCN(C)CCC2)c2ccccc21

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 8/20 0.57
ALDH1A1 P00352 3/20 0.53
HTT P42858 2/20 0.53
CYP3A4 P08684 2/20 0.53
MEN1 O00255 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
KMT2A Q03164 1/20 0.53
HTR4 Q13639 3/20 0.50
HTR3E A5X5Y0 1/20 0.49
SLC22A2 O15244 1/20 0.49
HTR3B O95264 1/20 0.49
CHRNB2 P17787 1/20 0.49
CHRNA3 P32297 1/20 0.49
CHRNA4 P43681 1/20 0.49
KCNH2 Q12809 1/20 0.49
HTR3D Q70Z44 1/20 0.49
HTR3C Q8WXA8 1/20 0.49
SLC47A1 Q96FL8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6956463 0.98 HTR3A (0.59) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL8162100 0.96 HTR3A (0.57) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL6953090 0.91 HTR3A (0.59) HTR3AALDH1A1HTTCYP3A4HTR4
SCHEMBL8173299 0.90 HTR3A (0.54) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL8173531 0.88 HTR3A (0.53) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL6947363 0.88 HTR3A (0.56) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL6950597 0.87 HTR3A (0.56) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL6956215 0.86 HTR3A (0.58) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL6950822 0.86 HTR3A (0.55) HTR3AALDH1A1HTTCYP3A4MEN1
SCHEMBL8172300 0.86 HTR4 (0.57) HTR3AALDH1A1HTTCYP3A4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6096746-A Indazole compound containing a monocyclic amine structure NISSHIN FLOUR MILLING CO., LTD. (JP) 2000-08-01 US disclosed
US-5945434-A TREATMENT OF GASTROINTESTINAL DISORDERS NISSHIN FLOUR MILLING CO., LTD. (JP) 1999-08-31 US disclosed
EP-0829474-A1 INDAZOLE DERIVATIVES HAVING MONOCYCLIC AMINO GROUP NISSHIN FLOUR MILLING CO., LTD. (JP) 1998-03-18 EP disclosed