Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795210 | 0.89 | SMN1; SMN2 (0.50) | PREPNPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL2099892 | 0.86 | TMEM97 (0.48) | PREPNPC1RAB9ANPSR1 | |
| SCHEMBL16143784 | 0.86 | TMEM97 (0.48) | PREPNPC1RAB9ANPSR1 | |
| SCHEMBL464252 | 0.86 | TMEM97 (0.48) | PREPNPC1RAB9ANPSR1 | |
| SCHEMBL2999647 | 0.85 | POLB (0.49) | FKBP1APREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9098331 | 0.85 | POLB (0.49) | FKBP1APREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6665516 | 0.85 | POLB (0.49) | FKBP1APREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3005973 | 0.85 | POLB (0.49) | FKBP1APREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15399834 | 0.84 | MITF (0.50) | FKBP1APREPMMP2NPSR1HTT | |
| SCHEMBL15399835 | 0.84 | MITF (0.50) | FKBP1APREPMMP2NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293915-B2 | Compounds and compositions as channel activating protease inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |
| US-8293915-B2 | Compounds and compositions as channel activating protease inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |
| US-20100056756-A1 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | IRM LLC (BM) | 2010-03-04 | — | — | US | disclosed |
| US-20100056756-A1 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | IRM LLC (BM) | 2010-03-04 | — | — | US | disclosed |
| WO-2008097676-A1 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | IRM LLC (BM) | 2008-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056756-A1 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | PRSS1, PRSS8, PRSS2 | FKBP1A 2148/4885PREP 102/4885NPC1 726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.