Azaserine

Azaserine

SCHEMBL81760

O=c1[nH]cnc2nc[nH]c12.[N-]=[N+]=CC(=O)OC[C@H](N)C(=O)O

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
SLC1A5 Q15758 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
PNP P00491 1/20 0.32
TP53 P04637 3/20 0.32
KDM4E B2RXH2 1/20 0.32
TSHR P16473 2/20 0.31
SLC2A1 P11166 1/20 0.31
CYP3A4 P08684 1/20 0.31
SLC7A5 Q01650 1/20 0.31
IDO1 P14902 1/20 0.30
GDA Q9Y2T3 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azaserine SCHEMBL20520234 1.00 ALDH1A1 (0.41) ALDH1A1SLC1A5SMN1; SMN2PNPTP53
SCHEMBL669596 0.79 CDC7 (0.39) SMN1; SMN2TP53KDM4ETSHRHSD17B10
Azaserine SCHEMBL8861 0.78 SLC1A5 (0.38) SLC1A5SLC7A5IDO1
Azaserine SCHEMBL8862 0.78 SLC1A5 (0.38) SLC1A5SLC7A5IDO1
Azaserine SCHEMBL3312110 0.78 SLC1A5 (0.38) SLC1A5SLC7A5IDO1
Azaserine SCHEMBL487222 0.78 SLC1A5 (0.38) SLC1A5SLC7A5IDO1
Doxribtimine SCHEMBL3514796 0.77 LMNA (0.48) TSHR
Azaserine SCHEMBL607082 0.77 SLC1A5 (0.37) SLC1A5SLC7A5IDO1
Azaserine SCHEMBL27500218 0.77 SLC1A5 (0.37) SLC1A5SLC7A5IDO1
Azathioprine SCHEMBL7757150 0.73 MAPT (0.62) ALDH1A1SMN1; SMN2TP53KDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 480 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240094218-A1 ENHANCED HYBRIDOMA GENERATION AMGEN INC. (US) 2024-03-21 US claimed
EP-4288450-A1 ENHANCED HYBRIDOMA GENERATION Amgen Inc. (US) 2023-12-13 EP claimed
US-20050148067-A1 Materials and methods for binding nucleic acids to surfaces LYLES MARK B (US) 2005-07-07 US claimed
US-6855817-B2 Materials and methods for binding nucleic acids to surfaces LYLES MARK B (US) 2005-02-15 US claimed
US-20020103350-A1 Materials and methods for binding nucleic acids to surfaces LYLES MARK B (US) 2002-08-01 US claimed
US-4950598-A Process for making T cell hybridomas THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1990-08-21 US claimed
US-4634666-A TRIOMAS SECRETING MONOCLONAL ANTIBODIES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1987-01-06 US claimed
US-20240174758-A1 THERAPEUTIC BINDING MOLECULES MEDIMMUNE LIMITED (GB) 2024-05-30 US disclosed
US-20240094218-A1 ENHANCED HYBRIDOMA GENERATION AMGEN INC. (US) 2024-03-21 US disclosed
EP-4308607-A2 THERAPEUTIC BINDING MOLECULE THAT BINDS TO CCR9 MedImmune Limited (GB) 2024-01-24 EP disclosed
EP-4304647-A1 ANTIBODIES DIRECTED AGAINST GDF-15 MedImmune, LLC (US) 2024-01-17 EP disclosed
US-11845791-B2 Antibodies directed against GDF-15 MEDIMMUNE, LLC (US) 2023-12-19 US disclosed
EP-4288450-A1 ENHANCED HYBRIDOMA GENERATION Amgen Inc. (US) 2023-12-13 EP disclosed
WO-1987005930-A1 IMMORTALIZED VIRUS-SPECIFIC TISSUE CELLS GENELABS INCORPORATED (US) 1987-10-08 WO disclosed
EP-0232411-A1 NON-HUMAN PRIMATE MONOCLONAL ANTIBODIES AND METHODS GENE LABS, INC. (US) 1987-08-19 EP disclosed
WO-1987001131-A1 NON-HUMAN PRIMATE MONOCLONAL ANTIBODIES AND METHODS GENE LABS, INC. (US) 1987-02-26 WO disclosed
US-4634666-A TRIOMAS SECRETING MONOCLONAL ANTIBODIES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1987-01-06 US disclosed
US-4624921-A CULTURES, FUSION CETUS CORPORATION (US) 1986-11-25 US disclosed
EP-0160550-A2 Human lymphoblastoid cell line and hybridomas derived therefrom and antibodies produced from such hybridomas, and the production and use of the aforesaid CETUS CORPORATION (US) 1985-11-06 EP disclosed
EP-0148644-A2 A novel fusion partner and its products THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1985-07-17 EP disclosed