Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 3/20 | 0.45 |
| ▸ | CASP7 | P55210 | 3/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.45 |
| ▸ | YWHAG | P61981 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11120339 | 0.82 | EIF2AK2 (0.62) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL13147782 | 0.82 | EIF2AK2 (0.50) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8171875 | 0.80 | EIF2AK2 (1.00) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL8172006 | 0.79 | EIF2AK2 (0.54) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL4846358 | 0.78 | EIF2AK2 (0.53) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL30821077 | 0.76 | EIF2AK2 (0.67) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL10349467 | 0.71 | EIF2AK2 (0.56) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL12960431 | 0.70 | MAPK13 (0.40) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL9286184 | 0.70 | EIF2AK2 (0.53) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 | |
| SCHEMBL15440804 | 0.69 | HTT (0.67) | EIF2AK2MAPK12MAPK13MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008091925-A2 | TREATMENT OF AORTIC DISSECTION OR ANEURYSM | COOK INCORPORATED (US) | 2008-07-31 | — | — | WO | disclosed |