Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 8/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8171209 | 0.92 | CYP1A2 (0.53) | LMNAMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL8179531 | 0.89 | CTNNB1 (0.47) | LMNAMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL8178013 | 0.89 | FYN (0.48) | LMNAMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL8178620 | 0.86 | LMNA (0.47) | LMNAMAPTMEN1KMT2APPARA | |
| SCHEMBL8179222 | 0.86 | PRKCI (0.50) | LMNAMAPTMEN1KMT2APPARA | |
| SCHEMBL5123659 | 0.85 | PDE5A (0.49) | LMNAMAPTMEN1KMT2APTGS2 | |
| SCHEMBL8178327 | 0.84 | MEN1 (0.55) | LMNAMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL8185246 | 0.84 | MEN1 (0.45) | LMNAMAPTMEN1KMT2APPARA | |
| SCHEMBL8177243 | 0.84 | MEN1 (0.47) | LMNAMEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL7018750 | 0.84 | PDE5A (0.52) | LMNAMAPTMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |