Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 11/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181963 | 0.90 | MET (0.44) | METKCNH2TSHRKMT2ATDP1 | |
| SCHEMBL7013401 | 0.90 | MET (0.40) | PDE5AMETKCNH2 | |
| SCHEMBL8178712 | 0.89 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DRHOA | |
| SCHEMBL8184409 | 0.89 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8178019 | 0.88 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DRHOA | |
| SCHEMBL8171169 | 0.88 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DRHOA | |
| SCHEMBL8181867 | 0.88 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DRHOA | |
| SCHEMBL7018675 | 0.86 | MET (0.43) | METKCNH2TSHRKMT2A | |
| SCHEMBL8187986 | 0.86 | PDE5A (0.43) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8182359 | 0.84 | CTNNB1 (0.53) | PDE4APDE4BPDE4CPDE4DCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |