Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018675 | 0.92 | MET (0.43) | METKCNH2 | |
| SCHEMBL8178194 | 0.90 | PDE4A (0.43) | METPDE5AKCNH2 | |
| SCHEMBL7018879 | 0.89 | PDE5A (0.42) | METPDE5A | |
| SCHEMBL7019976 | 0.89 | PDE5A (0.43) | PDE5A | |
| SCHEMBL7016414 | 0.89 | PDE5A (0.41) | METPDE5A | |
| SCHEMBL7015155 | 0.89 | PDE5A (0.42) | METPDE5A | |
| SCHEMBL7020117 | 0.89 | PDE5A (0.42) | METPDE5AKCNH2 | |
| SCHEMBL8181963 | 0.87 | MET (0.44) | METKCNH2 | |
| SCHEMBL7012148 | 0.85 | CTNNB1 (0.48) | — | |
| SCHEMBL7016859 | 0.84 | ACHE (0.40) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |