Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013401 | 0.92 | MET (0.40) | METKCNH2 | |
| SCHEMBL7018702 | 0.92 | JAK2 (0.39) | METJAK2JAK3PTK2KMT2A | |
| SCHEMBL7015708 | 0.91 | MET (0.39) | METJAK2JAK3PTK2 | |
| SCHEMBL8181963 | 0.90 | MET (0.44) | METKCNH2TSHRKMT2AEPHX2 | |
| SCHEMBL7018514 | 0.90 | MET (0.38) | METJAK2JAK3PTK2 | |
| SCHEMBL7015295 | 0.90 | MET (0.40) | METKCNH2JAK2JAK3PTK2 | |
| SCHEMBL7018883 | 0.89 | CTNNB1 (0.42) | — | |
| SCHEMBL8178194 | 0.86 | PDE4A (0.43) | METKCNH2TSHRKMT2A | |
| SCHEMBL7014936 | 0.86 | CTNNB1 (0.47) | — | |
| SCHEMBL7013933 | 0.86 | APP (0.39) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |