Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207598 | 0.82 | PNMT (0.36) | PNMT | |
| SCHEMBL206972 | 0.80 | MEN1 (0.33) | — | |
| SCHEMBL676941 | 0.78 | OPRM1 (0.33) | NOS3NOS1NOS2DAO | |
| SCHEMBL8181947 | 0.77 | GCGR (0.31) | DAO | |
| SCHEMBL3595125 | 0.77 | KMT2A (0.41) | — | |
| SCHEMBL5792075 | 0.76 | TAAR1 (0.44) | PNMT | |
| SCHEMBL7482400 | 0.76 | TAAR1 (0.49) | — | |
| SCHEMBL5328557 | 0.76 | MEN1 (0.37) | TSHR | |
| SCHEMBL456942 | 0.75 | — | — | |
| SCHEMBL1925068 | 0.74 | MEN1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143747-A | ENZYME INHIBITORS | G. D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6060476-A | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2000-05-09 | — | — | US | disclosed |
| US-5965588-A | COMPOUNDS PARTICULARLY USEFUL AS INHIBITORS OF HIV PROTEASE | G.D. SEARLE & CO. (US) | 1999-10-12 | — | — | US | disclosed |