Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 13/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 13/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170085 | 0.93 | CTNNB1 (0.48) | CTNNB1TCF7L2HRH4ALDH1A1 | |
| SCHEMBL8179602 | 0.90 | CTNNB1 (0.48) | CTNNB1TCF7L2MAPTPTPN11PDE5A | |
| SCHEMBL8184409 | 0.90 | PDE4A (0.47) | CTNNB1TCF7L2MAPTPDE5AHRH4 | |
| SCHEMBL8179254 | 0.89 | ICAM1 (0.48) | CTNNB1TCF7L2MAPTPTPN11PDE5A | |
| SCHEMBL8171286 | 0.89 | KDM4E (0.48) | CTNNB1TCF7L2MAPTPDE5AALDH1A1 | |
| SCHEMBL8181963 | 0.89 | MET (0.44) | MAPTTSHRKMT2AEPHX2 | |
| SCHEMBL7018883 | 0.89 | CTNNB1 (0.42) | CTNNB1TCF7L2PDE5AHRH4 | |
| SCHEMBL8180828 | 0.88 | MAPT (0.48) | CTNNB1TCF7L2MAPTPTPN11PDE5A | |
| SCHEMBL8169893 | 0.88 | ALDH1A1 (0.47) | CTNNB1TCF7L2PDE5AALDH1A1TSHR | |
| SCHEMBL8179892 | 0.87 | PDE4A (0.49) | CTNNB1TCF7L2MAPTPDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |
| US-5948911-A | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 1999-09-07 | — | — | US | disclosed |