Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 14/20 | 0.42 |
| ▸ | TCF7L2 | Q9NQB0 | 14/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014936 | 0.94 | CTNNB1 (0.47) | CTNNB1TCF7L2HRH4 | |
| SCHEMBL7019976 | 0.91 | PDE5A (0.43) | CTNNB1TCF7L2HRH4PDE5AHTR3A | |
| SCHEMBL7017246 | 0.90 | HRH4 (0.44) | CTNNB1TCF7L2HRH4PDE5AHTR3A | |
| SCHEMBL7020185 | 0.89 | CTNNB1 (0.39) | CTNNB1TCF7L2HRH4PDE5A | |
| SCHEMBL7018675 | 0.89 | MET (0.43) | — | |
| SCHEMBL8178702 | 0.89 | CTNNB1 (0.45) | CTNNB1TCF7L2HRH4PDE5A | |
| SCHEMBL7017144 | 0.89 | HRH4 (0.45) | CTNNB1TCF7L2HRH4PDE5AHTR3A | |
| SCHEMBL7019661 | 0.89 | ICAM1 (0.46) | CTNNB1TCF7L2HRH4PDE5AHTR3A | |
| SCHEMBL7013933 | 0.89 | APP (0.39) | CTNNB1TCF7L2PDE5A | |
| SCHEMBL7016442 | 0.87 | PDE4A (0.49) | CTNNB1TCF7L2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |