Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205756 | 0.82 | CYP1A2 (0.42) | GSRSLC9A1ADRA2AADRA2BADRA2C | |
| SCHEMBL8199653 | 0.80 | GABRA1 (0.44) | ADRA2BPTGS1PTGS2 | |
| SCHEMBL3694809 | 0.80 | LOXL2 (0.41) | GSRSLC9A1ADRA2C | |
| SCHEMBL12305567 | 0.80 | CYP4F2 (0.46) | GSRSLC9A1ADRA2AADRA2BADRA2C | |
| SCHEMBL12461197 | 0.78 | GSR (0.33) | GSR | |
| SCHEMBL18459013 | 0.77 | ADRA2A (0.40) | ADRA2AADRA2BADRA2C | |
| SCHEMBL18488267 | 0.77 | KDM4E (0.42) | GSRSLC9A1 | |
| SCHEMBL19695742 | 0.77 | GSR (0.55) | GSR | |
| SCHEMBL10821969 | 0.76 | THRA (0.46) | GSRADRA2BPTGS2 | |
| SCHEMBL10268025 | 0.76 | SKP2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063670-A1 | HETEROBICYCLIC MATRIX METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |