Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | GLI1 | P08151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL4596015 | 0.90 | MEN1 (0.41) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL4596023 | 0.90 | MEN1 (0.41) | NOS2NOS3NOS1MEN1BLM | |
| D-Proline SCHEMBL18493080 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 | |
| Proline SCHEMBL3097543 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 | |
| Proline SCHEMBL1125864 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 | |
| Proline SCHEMBL418934 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 | |
| Proline SCHEMBL302680 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 | |
| Proline SCHEMBL1675389 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 | |
| Proline SCHEMBL1429909 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 | |
| Proline SCHEMBL419844 | 0.88 | NOS2 (0.45) | NOS2NOS3NOS1GLI1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861254-A4 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6046198-A | NON-PEPTIDE AMIDE COMPOUNDS; STIMULATE HEMATOPOIESIS AND MAY BE USEFUL FOR TREATMENT OF VIRAL, FUNGAL AND BACTERIAL INFECTIOUS DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0861254-A1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997018213-A1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-22 | — | — | WO | disclosed |