Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL4596023 | 1.00 | MEN1 (0.41) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL8180643 | 0.90 | NOS2 (0.37) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL11588329 | 0.86 | MEN1 (0.42) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL28281079 | 0.86 | BLM (0.48) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL4309382 | 0.86 | BLM (0.48) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL2173873 | 0.86 | BLM (0.48) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL4309380 | 0.86 | BLM (0.48) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL10141185 | 0.85 | — | — | |
| Proline SCHEMBL462226 | 0.85 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL718906 | 0.85 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002001956-A1 | HISTIDYL-PROLINE DIKETOPIPERAZINE AND METHOD OF USE | PRASAD CHANDAN (US) | 2002-01-10 | — | — | WO | claimed |
| CN-105744945-B | Three peptide formulations of freeze-drying of stable storing | 广州领晟医疗科技有限公司 | 2019-07-02 | — | — | CN | disclosed |
| EP-1442741-B1 | Compositions and methods for treating obesity | US DEPT OF VETERANS AFFAIRES A (US) | 2008-01-16 | — | — | EP | disclosed |
| US-7144865-B2 | Compositions and methods for treating obesity | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040185125-A1 | Compositions and methods for treating obesity | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2004-09-23 | — | — | US | disclosed |
| EP-1442741-A1 | Compositions and methods for treating obesity | Moon, K. Song (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2002001956-A1 | HISTIDYL-PROLINE DIKETOPIPERAZINE AND METHOD OF USE | PRASAD CHANDAN (US) | 2002-01-10 | — | — | WO | disclosed |
| EP-0220958-A2 | Selective chemical removal of a protein amino-terminal residue | ELI LILLY AND COMPANY (US) | 1987-05-06 | — | — | EP | disclosed |