Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 6/20 | 0.41 |
| ▸ | APP | P05067 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187926 | 0.93 | PDE5A (0.52) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8169893 | 0.92 | ALDH1A1 (0.47) | PDE5ATP53CTNNB1TCF7L2CCR4 | |
| SCHEMBL7016859 | 0.91 | ACHE (0.40) | PDE5ATP53CTNNB1TCF7L2ACHE | |
| SCHEMBL8185751 | 0.89 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8179769 | 0.89 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8177126 | 0.88 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7013933 | 0.87 | APP (0.39) | PDE5ATP53CTNNB1TCF7L2ACHE | |
| SCHEMBL8182359 | 0.87 | CTNNB1 (0.53) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8184409 | 0.87 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8180943 | 0.86 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |