Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL718707 | 1.00 | HCAR2 (0.46) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL10917789 | 0.80 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL2469636 | 0.80 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL2469635 | 0.80 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL76624 | 0.79 | — | — | |
| Fumaric Acid SCHEMBL8722977 | 0.78 | TSHR (0.45) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL23795124 | 0.76 | TP53 (0.33) | TSHRTP53GAATDP1 | |
| SCHEMBL10407817 | 0.76 | — | — | |
| SCHEMBL1352111 | 0.70 | — | — | |
| Fumaric Acid SCHEMBL20455851 | 0.70 | TSHR (0.64) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014921-A1 | ENZYMATIC FOAM COMPOSITIONS FOR DYEING KERATINOUS FIBRES | NOVO NORDISK A/S (DK) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999015137-A1 | ENZYMATIC FOAM COMPOSITIONS FOR DYEING KERATINOUS FIBRES | NOVO NORDISK A/S (DK) | 1999-04-01 | — | — | WO | disclosed |
| EP-0177765-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1990-03-14 | — | — | EP | disclosed |