Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8181535 | 1.00 | HCAR2 (0.46) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL10917789 | 0.80 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL2469636 | 0.80 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL2469635 | 0.80 | HCAR2 (0.63) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL76624 | 0.79 | — | — | |
| Fumaric Acid SCHEMBL8722977 | 0.78 | TSHR (0.45) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL23795124 | 0.76 | TP53 (0.33) | TSHRTP53GAATDP1 | |
| SCHEMBL10407817 | 0.76 | — | — | |
| SCHEMBL1352111 | 0.70 | — | — | |
| Fumaric Acid SCHEMBL20455851 | 0.70 | TSHR (0.64) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11369553-B2 | Therapeutic oral composition | COLGATE-PALMOLIVE COMPANY (US) | 2022-06-28 | — | — | US | disclosed |
| US-20170128340-A1 | THERAPEUTIC ORAL COMPOSITION | COLGATE-PALMOLIVE COMPANY (US) | 2017-05-11 | — | — | US | disclosed |
| US-20120052025-A1 | BORINIC COMPOSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 2012-03-01 | — | — | US | disclosed |
| EP-0177765-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1990-03-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052025-A1 | BORINIC COMPOSITIONS | CCL11, BDKRB2, BTD | HCAR2 676/4885TSHR 4588/4885TP53 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.