Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | LITAF | Q99732 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870966 | 1.00 | METAP2 (0.37) | METAP2TSHRNPSR1CRHBPCRHR2 | |
| SCHEMBL870965 | 1.00 | METAP2 (0.37) | METAP2TSHRNPSR1CRHBPCRHR2 | |
| SCHEMBL871727 | 0.94 | PDE4B (0.39) | METAP2TSHRNPSR1CRHBPCRHR2 | |
| SCHEMBL872430 | 0.90 | CHKA (0.41) | — | |
| SCHEMBL871025 | 0.90 | CHKA (0.41) | — | |
| SCHEMBL870887 | 0.90 | VCP (0.37) | TSHRNPSR1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL870886 | 0.90 | VCP (0.37) | TSHRNPSR1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL870187 | 0.89 | PDE4B (0.41) | TSHRNPSR1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL870188 | 0.89 | PDE4B (0.41) | TSHRNPSR1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL3029957 | 0.89 | PDE4B (0.43) | ALDH1A1MEN1KMT2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |