Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49759 | 0.76 | ALDH1A1 (0.48) | CTSDRAB9ASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL12198931 | 0.71 | CTSD (0.48) | CTSDRAB9AMDM2LMNAL3MBTL1 | |
| SCHEMBL4960529 | 0.70 | LMNA (0.44) | RAB9ALMNAHTTKDM4E | |
| SCHEMBL198103 | 0.69 | — | — | |
| SCHEMBL183576 | 0.69 | — | — | |
| SCHEMBL1466441 | 0.69 | — | — | |
| SCHEMBL18375605 | 0.67 | KDM4E (0.38) | CTSDRAB9AMDM2L3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL8900134 | 0.67 | CTSD (0.48) | CTSDRAB9AMDM2LMNAL3MBTL1 | |
| Propanol SCHEMBL7328516 | 0.67 | CTSD (0.42) | CTSDRAB9AMDM2LMNASMN1; SMN2 | |
| SCHEMBL288700 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005470-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2000-06-07 | — | — | EP | claimed |
| WO-1999010349-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 1999-03-04 | — | — | WO | claimed |