SCHEMBL8183188

SCHEMBL8183188

COc1cc(F)cc(F)c1-n1c(=O)cc(C(F)(F)F)n(C)c1=O

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 1/20 0.36
PARK7 Q99497 1/20 0.33
BCAT1 P54687 2/20 0.32
BCAT2 O15382 1/20 0.32
CRHR1 P34998 1/20 0.32
CYP19A1 P11511 2/20 0.31
NQO2 P16083 2/20 0.31
CYP1A2 P05177 1/20 0.30
S100B P04271 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8180317 0.88 BCAT2 (0.36) GRM4BCAT1BCAT2CRHR1CYP1A2
SCHEMBL8176239 0.83 MAOB (0.31)
SCHEMBL8176724 0.82 GRM4 (0.30) GRM4
SCHEMBL8914465 0.80 BCAT1 (0.37) GRM4BCAT1BCAT2CYP1A2S100B
SCHEMBL6970318 0.77 GRM4 (0.32) GRM4
SCHEMBL10576721 0.75 BCAT1 (0.46) GRM4BCAT1BCAT2
SCHEMBL7881673 0.75 CRHR1 (0.34) GRM4BCAT1BCAT2CRHR1CYP1A2
SCHEMBL5391301 0.75 BCAT2 (0.32) BCAT1BCAT2
SCHEMBL7657861 0.75 BCAT2 (0.32) BCAT1BCAT2
SCHEMBL7668209 0.75 BCAT2 (0.32) BCAT1BCAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6130187-A Benzofuran-7-yl uracil derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-10-10 US disclosed
EP-0881223-A1 BENZOFURAN-7-YLURACIL DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-12-02 EP disclosed