Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505500 | 0.86 | ALDH1A1 (0.43) | ALDH1A1BCHEACHECYP1A2KDM4E | |
| SCHEMBL6957700 | 0.78 | DRD3 (0.45) | ALDH1A1GAAKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL6959886 | 0.76 | ALDH1A1 (0.53) | CHRNA7HTR3AALDH1A1CYP1A2KDM4E | |
| SCHEMBL3505067 | 0.75 | ACHE (0.40) | ALDH1A1BCHEACHEGAATDP1 | |
| SCHEMBL3507456 | 0.74 | EPHX2 (0.41) | ALDH1A1BCHEACHEGAATDP1 | |
| SCHEMBL8947062 | 0.72 | ACHE (0.42) | ALDH1A1BCHEACHEGAATDP1 | |
| SCHEMBL6951008 | 0.71 | HRH3 (0.41) | ALDH1A1BCHEACHE | |
| SCHEMBL3504376 | 0.70 | GRM4 (0.41) | ALDH1A1ACHEGAALMNATSHR | |
| SCHEMBL3504880 | 0.70 | ALDH1A1 (0.56) | ALDH1A1CYP1A2KDM4ELMNATSHR | |
| SCHEMBL8375998 | 0.69 | GAA (0.37) | HTR3AALDH1A1BCHEACHEGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046203-A | USEFUL FOR THE TREATMENT OF VARIOUS MEMORY DYSFUNCTIONS CHARACTERIZED BY A DECREASED CHOLINERGIC FUNCTION SUCH AS ALZHEIMER'S DISEASE; ALSO INHIBIT MONOAMINE OXIDASE AND HENCE ARE USEFUL AS ANTIDEPRESSANTS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |