Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 5/20 | 0.37 |
| ▸ | ACHE | P22303 | 5/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377217 | 0.88 | HTR2A (0.42) | GAATDP1HTR3AMMP3MEN1 | |
| SCHEMBL8377107 | 0.87 | CYP1A2 (0.39) | GAATDP1LMNAHPGDKDM4E | |
| SCHEMBL3504561 | 0.82 | ALDH1A1 (0.46) | GAATDP1LMNAHPGDKDM4E | |
| SCHEMBL8376040 | 0.81 | DRD3 (0.40) | GAATDP1LMNAHPGDKDM4E | |
| SCHEMBL8376002 | 0.77 | L3MBTL1 (0.39) | GAALMNAALDH1A1KMT2A | |
| SCHEMBL3505067 | 0.77 | ACHE (0.40) | GAATDP1LMNAHPGDKDM4E | |
| SCHEMBL3504318 | 0.77 | ACHE (0.41) | GAATDP1LMNAHPGDKDM4E | |
| SCHEMBL3505069 | 0.76 | GAA (0.45) | GAATDP1LMNAHPGDKDM4E | |
| SCHEMBL6956977 | 0.75 | ACHE (0.39) | ALDH1A1NPSR1BCHEACHEMEN1 | |
| SCHEMBL8377175 | 0.74 | CASR (0.40) | KDM4EALDH1A1HSD17B10NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925766-A | COGNITION ACTIVATORS FOR DECREASING CHOLINERGIC FUNCTION OF ALZHEIMER*S DISEASE AND ARE ENZYME INHIBITORS OF MONOAMINE OXIDASE AND ARE ANTIDEPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5756754-A | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-26 | — | — | US | disclosed |