Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1F | P30939 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189062 | 0.92 | DRD2 (0.36) | DRD2HTR2AHTR1BHTR6SLC6A4 | |
| SCHEMBL8189063 | 0.92 | DRD2 (0.36) | DRD2HTR2AHTR1BHTR6SLC6A4 | |
| SCHEMBL8182800 | 0.80 | DRD2 (0.41) | DRD2HTR2AHTR1BHTR6SLC6A4 | |
| SCHEMBL8196551 | 0.75 | HTR1D (0.62) | DRD2HTR2AHTR1BHTR1AHTR1D | |
| SCHEMBL6642794 | 0.74 | DRD2 (0.43) | DRD2HTR2AHTR1BHTR6SLC6A4 | |
| SCHEMBL12128712 | 0.73 | APP (0.44) | DRD2HTR2AHTR1BHTR6SLC6A4 | |
| SCHEMBL7710645 | 0.72 | DRD2 (0.54) | DRD2HTR2AHTR1BHTR6 | |
| SCHEMBL7019936 | 0.72 | HTR6 (0.41) | DRD2HTR2AHTR6SLC6A4 | |
| SCHEMBL7016909 | 0.71 | DRD2 (0.53) | DRD2HTR2AHTR1BHTR6SLC6A4 | |
| SCHEMBL12128118 | 0.70 | APP (0.46) | DRD2HTR1BHTR6RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000000490-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |