Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196909 | 0.86 | IKBKB (0.43) | MAPTMEN1LMNAKMT2ACCNE2 | |
| SCHEMBL8199933 | 0.83 | IKBKB (0.37) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL8642444 | 0.80 | GSK3B (0.45) | MAPTMEN1LMNAKMT2AL3MBTL1 | |
| SCHEMBL8194840 | 0.80 | MAPT (0.37) | MAPTMEN1LMNAKMT2AATM | |
| SCHEMBL8196103 | 0.79 | GRK6 (0.38) | MAPTMEN1LMNAKMT2AATM | |
| SCHEMBL8188370 | 0.79 | MAPK14 (0.39) | MAPTMEN1LMNAKMT2AATM | |
| SCHEMBL8639382 | 0.78 | MAPK14 (0.44) | GSK3BMAPK14ALOX5MAPK13MAPK12 | |
| SCHEMBL8201297 | 0.74 | L3MBTL1 (0.37) | MAPTMEN1LMNAKMT2AATM | |
| SCHEMBL21507968 | 0.73 | ENPP3 (0.46) | — | |
| SCHEMBL8195709 | 0.73 | GSK3B (0.41) | CDK2GSK3BMAPK14NOTUMIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |