Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195834 | 0.91 | IKBKE (0.39) | GRK6MAPTTHRBTP53SMN1; SMN2 | |
| SCHEMBL8195725 | 0.88 | RPS6KA3 (0.40) | GRK6MAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL8200074 | 0.88 | LMNA (0.38) | MAPTLMNATHRBL3MBTL1MEN1 | |
| SCHEMBL8195495 | 0.85 | TP53 (0.37) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL8197299 | 0.83 | MAPK14 (0.38) | MAPTL3MBTL1MEN1KMT2ATP53 | |
| SCHEMBL8199147 | 0.83 | KMO (0.36) | GRK6MAPTLMNAMEN1KMT2A | |
| SCHEMBL8200073 | 0.81 | FFAR1 (0.35) | GRK6MAPTL3MBTL1ALDH1A1FFAR1 | |
| SCHEMBL8187489 | 0.79 | MAPT (0.39) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL8201297 | 0.72 | L3MBTL1 (0.37) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL8188370 | 0.71 | MAPK14 (0.39) | GRK6MAPTLMNAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |