Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298948 | 0.90 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL1371070 | 0.88 | KEAP1 (0.61) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL5674267 | 0.87 | HDAC1 (0.75) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13089543 | 0.85 | HDAC1 (0.60) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL11250780 | 0.83 | HDAC1 (0.50) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27831457 | 0.83 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL19561359 | 0.83 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL9404033 | 0.83 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL8664876 | 0.82 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL4886613 | 0.81 | MAPT (0.73) | HDAC1HDAC3HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040289-A | ACTIVE DRUG TREATING OBESITY | DR. KARL THOMAE GMBH (DE) | 2000-03-21 | — | — | US | disclosed |
| EP-0865426-A1 | AMINO ACID DERIVATIVES, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHODS OF PRODUCING SAID COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997019914-A1 | AMINO ACID DERIVATIVES, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHODS OF PRODUCING SAID COMPOUNDS | DR. KARL THOMAE GMBH (DE) | 1997-06-05 | — | — | WO | disclosed |
| US-4325967-A | Cyclopentane derivatives | MAY & BAKER LIMITED (GB) | 1982-04-20 | — | — | US | disclosed |
| US-4183870-A | Cyclopentane derivatives | MAY & BAKER LIMITED (GB) | 1980-01-15 | — | — | US | disclosed |