Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | PPOX | P50336 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186323 | 0.91 | PPOX (0.38) | BRD4PPOXMCL1POLBMAPT | |
| SCHEMBL5774516 | 0.81 | BRD4 (0.45) | BRD4ALOX5APFEN1PPOXHAVCR2 | |
| SCHEMBL8189287 | 0.80 | COMT (0.40) | RORCLMNA | |
| SCHEMBL8177457 | 0.80 | ALDH1A1 (0.33) | BRD4ALOX5APFEN1POLBMAPT | |
| SCHEMBL8187607 | 0.78 | MAPK1 (0.35) | LMNAWDR5 | |
| SCHEMBL8192247 | 0.78 | PPOX (0.36) | ALOX5APFEN1PPOXPOLBMAPT | |
| SCHEMBL8189134 | 0.77 | TDP1 (0.35) | POLBMAPTLMNAHTT | |
| SCHEMBL8189074 | 0.76 | MEN1 (0.34) | PPOXPOLBL3MBTL1WDR5 | |
| SCHEMBL8179014 | 0.75 | HSD11B1 (0.45) | — | |
| SCHEMBL8174020 | 0.74 | MCL1 (0.35) | BRD4PPOXMCL1MAPTRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015774-A | Pyrazin-2-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-01-18 | — | — | US | disclosed |
| CN-1202159-A | Pyrazin-2-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL CO (JP) | 1998-12-16 | — | — | CN | disclosed |