Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 13/20 | 0.75 |
| ▸ | MMP1 | P03956 | 10/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.74 |
| ▸ | PGR | P06401 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.72 |
| ▸ | AR | P10275 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | APEX1 | P27695 | 1/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.72 |
| ▸ | CHUK | O15111 | 1/20 | 0.72 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.72 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL472227 | 1.00 | NR3C1 (0.75) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL1048586 | 1.00 | NR3C1 (0.75) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL15568326 | 0.95 | NR3C1 (0.73) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL2898449 | 0.93 | NR3C1 (0.76) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL15671680 | 0.93 | NR3C1 (0.76) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL73249 | 0.93 | NR3C1 (0.76) | NR3C1MMP1CYP3A4PGRMEN1 | |
| Water SCHEMBL201856 | 0.92 | NR3C1 (0.75) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL2123848 | 0.92 | NR3C1 (0.75) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL3836633 | 0.92 | NR3C1 (0.75) | NR3C1MMP1CYP3A4PGRMEN1 | |
| SCHEMBL3126388 | 0.92 | NR3C1 (0.75) | NR3C1MMP1CYP3A4PGRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3946265-B1 | OTOLOGIC COMPOSITIONS | NTC S R L (IT) | 2024-12-04 | — | — | EP | claimed |
| CN-114381768-B | Preparation method for constructing photodynamic antibacterial bone dexamethasone/hydroxyapatite coating by polypyrrole regulated copper nano particles | 新疆师范大学 | 2024-02-06 | — | — | CN | claimed |
| CN-114381768-A | Preparation method of photodynamic antibacterial osteogenesis-promoting dexamethasone/hydroxyapatite coating constructed by polypyrrole-regulated copper nanoparticles | 新疆师范大学 | 2022-04-22 | — | — | CN | claimed |
| CN-113677327-A | Otological compositions | NTC有限公司 | 2021-11-19 | — | — | CN | claimed |
| CN-107532201-B | Method for assessing response of patients with ataxia telangiectasia to glucocorticoid therapy | 爱瑞德勒股份有限公司 | 2021-05-11 | — | — | CN | claimed |
| US-9028860-B2 | Partially microcellular, selectively hydrophilic composite construct for ocular drug delivery | POLY-MED, INC. (US) | 2015-05-12 | — | — | US | claimed |
| WO-2014061937-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL ADMINISTRATION COMPRISING PIPERACILLIN OR ITS SALT, TAZOBACTAM OR ITS SALT AND DEXAMETHASONE PHOSPHATE OR ITS SALT | YUHAN CORPORATION (KR) | 2014-04-24 | — | — | WO | claimed |
| WO-2014010924-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL ADMINISTRATION COMPRISING VANCOMYCIN OR ITS SALT AND DEXAMETHASONE PHOSPHATE OR ITS SALT | YUHAN CORPORATION (KR) | 2014-01-16 | — | — | WO | claimed |
| US-20110268783-A1 | PARTIALLY MICROCELLULAR, SELECTIVELY HYDROPHILIC COMPOSITE CONSTRUCT FOR OCULAR DRUG DELIVERY | POLY-MED, INC. (US) | 2011-11-03 | — | — | US | claimed |
| EP-1913948-B1 | Re-epithelializing pharmaceutical compositions containing xanthan gum | SIFI SPA (IT) | 2011-10-12 | — | — | EP | claimed |
| WO-2011031018-A2 | WATER-SOLUBLE DRUG DELIVERY SYSTEM ALLOWING SLOW RELEASE | 한남대학교 산학협력단 (KR) | 2011-03-17 | — | — | WO | claimed |
| US-20080146530-A1 | Dexamethasone disodium phosphate; netilmicin sulfate; xanthan gum; sodium (di)hydrogen phosphate buffer; sodium citrate; and water; ophthalmology; vision defects; corneal epithelial cells; wound healing agents | SIFI S.P.A. (IT) | 2008-06-19 | — | — | US | claimed |
| EP-1913948-A1 | Re-epithelializing pharmaceutical compositions containing xanthan gum | Sifi S.p.A (IT) | 2008-04-23 | — | — | EP | claimed |
| US-20080038316-A1 | Conveniently implantable sustained release drug compositions | RAMSCOR, INC. | 2008-02-14 | — | — | US | claimed |
| US-20050234011-A1 | Use of composition of xanthan gum mixed with hyaluronic acid speeds up and improves advantageously the formation of newly grown epithelium, especially of corneal tissue | SIFI S.P.A. (IT) | 2005-10-20 | — | — | US | claimed |
| EP-1358883-A1 | Re-epithelializing pharmaceutical compositions containing xanthan gum | Sifi S.p.A (IT) | 2003-11-05 | — | — | EP | claimed |
| US-5147291-A | Sound transmission apparatus for uniformly administering chemical composition through the skin | CUKIER A DAVID (US) | 1992-09-15 | — | — | US | claimed |
| EP-4373495-B1 | BUDESONIDE 21-PHOSPHATE SODIUM SALT FOR USE AS ANTI-INFLAMMATORY OR ANTI-ASTHMATIC AGENT | GENETIC S P A (IT) | 2025-11-19 | — | — | EP | disclosed |
| US-4432964-A | Topical composition containing steroid in two forms released independently from polymeric carrier | ALZA CORPORATION (US) | 1984-02-21 | — | — | US | disclosed |
| US-4304765-A | Ocular insert housing steroid in two different therapeutic forms | ALZA CORPORATION (US) | 1981-12-08 | — | — | US | disclosed |