SCHEMBL8190761

SCHEMBL8190761

CCON=C(C(CC)=C(ON)c1ccccc1C(=C=NC)C(=O)OC)c1ccc(Oc2cccc(C(F)(F)F)c2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.36
HIF1A Q16665 1/20 0.35
CHEK2 O96017 1/20 0.34
GCGR P47871 1/20 0.33
TLR8 Q9NR97 1/20 0.33
TLR7 Q9NYK1 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
KDM4E B2RXH2 1/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
MAPT P10636 1/20 0.32
BTK Q06187 1/20 0.32
MMP2 P08253 1/20 0.31
MMP3 P08254 1/20 0.31
MMP9 P14780 1/20 0.31
MMP8 P22894 1/20 0.31
MMP13 P45452 1/20 0.31
MMP14 P50281 1/20 0.31
NR3C1 P04150 1/20 0.31
PGR P06401 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8196231 0.92 MAPK14 (0.36) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL8180161 0.86 MAPK14 (0.39) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL8190757 0.83 HIF1A (0.41) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL8190754 0.83 HIF1A (0.41) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL7467262 0.80 MAPK14 (0.39) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL8544631 0.79 MAPK14 (0.37) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL7498151 0.77 HIF1A (0.46) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL8196227 0.75 HIF1A (0.36) MAPK14HIF1AGCGRTLR8TLR7
SCHEMBL7494028 0.73 MAPK14 (0.39) MAPK14HIF1ACHEK2GCGRTLR8
SCHEMBL7470568 0.72 MAPK14 (0.38) MAPK14HIF1AKDM4EHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0984924-A1 O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES Novartis AG (CH) 2000-03-15 EP disclosed
WO-1998054126-A1 O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES NOVARTIS AG (CH) 1998-12-03 WO disclosed