Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8176435 | 0.88 | DRD2 (0.61) | DRD2HTR6HTR1BSLC6A4GSK3B | |
| SCHEMBL6313386 | 0.80 | MTNR1A (0.46) | DRD2HTR6SLC6A4MEN1KMT2A | |
| SCHEMBL6308711 | 0.79 | USP2 (0.47) | DRD2SLC6A4ALDH1A1LMNACYP1A2 | |
| SCHEMBL8185072 | 0.77 | DRD2 (0.50) | DRD2HTR6HTR1BSLC6A4HTR2A | |
| SCHEMBL6308994 | 0.77 | HTR1A (0.54) | DRD2HTR1BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7816263 | 0.76 | CYP1A2 (0.57) | DRD2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6307121 | 0.76 | HTR1D (0.57) | DRD2HTR6HTR1BSLC6A4HTR2A | |
| SCHEMBL7256238 | 0.75 | DRD2 (0.69) | DRD2HTR6HTR1BSLC6A4HTR2A | |
| SCHEMBL9325324 | 0.74 | MTNR1A (0.56) | DRD2HTR1BSLC6A4MEN1KMT2A | |
| Bromide SCHEMBL9325759 | 0.73 | DRD2 (0.68) | DRD2HTR6HTR1BSLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1064350-C | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 2001-04-11 | — | — | CN | disclosed |
| US-6166020-A | Aryl and heteroaryl alkoxynaphthalene derivatives | PFIZER INC. (US) | 2000-12-26 | — | — | US | disclosed |
| US-5821245-A | Use of naphthalene derivatives in treating lung carcinoma | PFIZER INC. (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0795328-A1 | Use of naphthalene derivatives in treating lung carcinoma | PFIZER INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| CN-1151729-A | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 1997-06-11 | — | — | CN | disclosed |
| EP-0767782-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000720-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1996-01-11 | — | — | WO | disclosed |