Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313386 | 0.90 | MTNR1A (0.46) | MTNR1AMTNR1BDRD2SLC6A4MEN1 | |
| SCHEMBL6308711 | 0.89 | USP2 (0.47) | MTNR1ADRD2SLC6A4HTR1AFDFT1 | |
| SCHEMBL7102201 | 0.88 | MTNR1A (0.64) | MTNR1AMTNR1B | |
| SCHEMBL1387940 | 0.85 | HTR6 (0.46) | MTNR1AMTNR1BDRD2SLC6A4HTR1A | |
| SCHEMBL9675325 | 0.82 | MTNR1A (0.61) | MTNR1AMTNR1BSLC6A4HTR1A | |
| SCHEMBL7810666 | 0.82 | MTNR1A (0.41) | MTNR1AMTNR1BDRD2SLC6A4HTR1A | |
| SCHEMBL8185072 | 0.81 | DRD2 (0.50) | DRD2SLC6A4HTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL9327308 | 0.81 | MTNR1A (0.60) | MTNR1AMTNR1BSLC6A4HTR1A | |
| SCHEMBL6306397 | 0.80 | HTR6 (0.48) | MTNR1ADRD2SLC6A4DRD1 | |
| SCHEMBL9676867 | 0.80 | MTNR1A (0.51) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278185-A | Piperidine, Tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5260317-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5250544-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-10-05 | — | — | US | disclosed |
| US-5242933-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-09-07 | — | — | US | disclosed |
| US-5240942-A | Hypotensive agents; 5-hydroxytryptamine antagonist | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0466585-A1 | Novel piperidin, tetrahydropyridine and pyrrolidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-01-15 | — | — | EP | disclosed |