Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037246 | 0.75 | SIGMAR1 (0.40) | SIGMAR1DRD2SLC6A9OPRM1SLC6A5 | |
| SCHEMBL2879213 | 0.74 | SLC6A9 (0.38) | SIGMAR1DRD2SLC6A9OPRM1SLC6A5 | |
| Hydrochloric Acid SCHEMBL9037991 | 0.73 | SIGMAR1 (0.39) | SIGMAR1DRD2SLC6A9OPRM1SLC6A5 | |
| SCHEMBL15568523 | 0.70 | TAAR1 (0.41) | SIGMAR1DRD2OPRM1MAPTTAAR1 | |
| SCHEMBL17135722 | 0.70 | OPRM1 (0.44) | SIGMAR1DRD2OPRM1MAPTTAAR1 | |
| SCHEMBL16221385 | 0.68 | KDM1A (0.46) | SIGMAR1DRD2OPRM1MAPTTAAR1 | |
| SCHEMBL32672366 | 0.68 | KDM1A (0.41) | SIGMAR1DRD2OPRM1MAPTTAAR1 | |
| SCHEMBL15571072 | 0.67 | TAAR1 (0.39) | SIGMAR1DRD2OPRM1MAPTTAAR1 | |
| Hydrochloric Acid SCHEMBL5505790 | 0.66 | TAAR1 (0.39) | DRD2MAPTTAAR1KDM1AMAOB | |
| SCHEMBL1138335 | 0.64 | SLC6A9 (0.56) | SLC6A9OPRM1SLC6A5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |
| EP-0696280-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMA (US) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994026735-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-24 | — | — | WO | disclosed |