SCHEMBL8192516

SCHEMBL8192516

Cc1ccc(S(=O)(=O)N2CCN(S(=O)(=O)c3ccc(C)cc3)CCN(S(=O)(=O)c3ccc(C)cc3)CC(Cc3ccccc3)N(S(=O)(=O)c3ccc(C)cc3)CCN(S(=O)(=O)c3ccc(C)cc3)CC2)cc1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.55
PKM P14618 2/20 0.55
NPSR1 Q6W5P4 1/20 0.53
ALDH1A1 P00352 5/20 0.53
KMT2A Q03164 3/20 0.53
LMNA P02545 1/20 0.53
CA1 P00915 4/20 0.52
CA2 P00918 4/20 0.52
CA4 P22748 4/20 0.52
CA9 Q16790 4/20 0.52
ELANE P08246 1/20 0.51
POLB P06746 2/20 0.50
HTT P42858 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
MAPT P10636 1/20 0.49
MEN1 O00255 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9273582 0.88 ALDH1A1 (0.54) GAAPKMALDH1A1KMT2ALMNA
SCHEMBL5556846 0.87 GAA (0.52) GAAPKMNPSR1ALDH1A1KMT2A
SCHEMBL3832918 0.86 NPSR1 (0.55) GAAPKMNPSR1ALDH1A1LMNA
SCHEMBL3832921 0.86 NPSR1 (0.55) GAAPKMNPSR1ALDH1A1LMNA
SCHEMBL9540293 0.85 ALDH1A1 (0.49) PKMALDH1A1KMT2ALMNAPOLB
SCHEMBL9485554 0.82 KMT2A (0.60) GAAPKMALDH1A1KMT2ALMNA
SCHEMBL8205234 0.81 KMT2A (0.56) GAAPKMALDH1A1KMT2ALMNA
SCHEMBL4092772 0.80 LMNA (0.52) ALDH1A1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL8696934 0.80 GCKR (0.50) GAAPKMALDH1A1KMT2ALMNA
SCHEMBL3813872 0.79 MEN1 (0.75) GAAPKMNPSR1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6084093-A SUBSTITUTED 1,4,7,10,13-PENTAAZACYCLOPENTADECANE MACROCYCLIC LIGANDS; MANGANESE COMPLEXES OF THE LIGAND ARE MIMICS OF SUPEROXIDE DISMUTASE; USEFUL AS THERAPEUTIC AGENTS FOR INFLAMMATORY DISEASES G. D. SEARLE & CO. (US) 2000-07-04 US disclosed
US-5874421-A Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide G. D. SEARLE & CO. (US) 1999-02-23 US disclosed
EP-0598753-B1 MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE MONSANTO CO (US) 1998-03-18 EP disclosed
US-5637578-A AGENTS FOR INFLAMMATION, ISCHEMIC/REPERFUSION INJURY, STROKE, ATHEROSCLEROSIS, AND HYPERTENSION MONSANTO COMPANY 1997-06-10 US disclosed
US-5610293-A TREATMENT OF INFLAMMATORY DISEASES, ISCHEMIC/REPERFUSION INJURY, STROKE, ATHERSCLEROSIS, HYPERTENSION MONSANTO COMPANY (US) 1997-03-11 US disclosed
EP-0598753-A1 MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE MONSANTO COMPANY (US) 1994-06-01 EP disclosed
WO-1993002090-A1 MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE MONSANTO COMPANY (US) 1993-02-04 WO disclosed
EP-0524161-A1 Manganese complexes of nitrogen containing macrocyclic ligands effective as catalysts for dismutating superoxide MONSANTO COMPANY (US) 1993-01-20 EP disclosed