Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817734 | 0.78 | HTR7 (0.44) | ABCB1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL9033236 | 0.78 | DRD4 (0.42) | DRD2DRD3SIGMAR1TMEM97HTR7 | |
| SCHEMBL7822680 | 0.76 | ABCB1 (0.41) | ABCB1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL6999334 | 0.72 | HTR1A (0.46) | ABCB1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7809525 | 0.70 | DRD4 (0.42) | SIGMAR1TMEM97HTR7DRD4 | |
| SCHEMBL7819620 | 0.67 | DRD4 (0.40) | SIGMAR1TMEM97HTR7DRD4 | |
| SCHEMBL7818896 | 0.67 | HTR7 (0.45) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL10732981 | 0.66 | HTR1A (0.47) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7977889 | 0.66 | HTR1A (0.78) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL6774810 | 0.66 | DRD3 (0.44) | ABCB1HTR1ADRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100265-A | BENZOTHIOPYRAN AND THIENOTHIOPYRAN DERIVATIVES; SEROTONIN-2 BLOCKING ACTION; TREATMENT OF CIRCULATORY DISEASES IN GENERAL SUCH AS HYPERTENSION, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE | SUNTORY LIMITED (JP) | 2000-08-08 | — | — | US | disclosed |