SCHEMBL8195099

SCHEMBL8195099

O=C(O)C=Cc1ccc(NC(=O)Nc2ccccc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.62
HDAC8 Q9BY41 2/20 0.62
HDAC6 Q9UBN7 2/20 0.62
HCAR2 Q8TDS4 2/20 0.62
HDAC3 O15379 1/20 0.62
TNKS O95271 1/20 0.62
HDAC4 P56524 1/20 0.62
HDAC7 Q8WUI4 1/20 0.62
HDAC2 Q92769 1/20 0.62
HDAC10 Q969S8 1/20 0.62
HDAC11 Q96DB2 1/20 0.62
TNKS2 Q9H2K2 1/20 0.62
HDAC9 Q9UKV0 1/20 0.62
HDAC5 Q9UQL6 1/20 0.62
TP53 P04637 1/20 0.61
EPHX1 P07099 1/20 0.61
TSHR P16473 1/20 0.61
EPHX2 P34913 1/20 0.61
CDK9 P50750 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8195098 1.00 HDAC1 (0.62) HDAC1HDAC8HDAC6HCAR2HDAC3
SCHEMBL11996395 0.87 SMN1; SMN2 (0.68) TP53EPHX1TSHREPHX2CDK9
SCHEMBL11996396 0.87 SMN1; SMN2 (0.68) TP53EPHX1TSHREPHX2CDK9
SCHEMBL292963 0.85 HCAR2 (0.67) HDAC1HDAC8HDAC6HCAR2HDAC3
SCHEMBL292964 0.85 HCAR2 (0.67) HDAC1HDAC8HDAC6HCAR2HDAC3
SCHEMBL7747810 0.85 RAB9A (0.64) SMN1; SMN2KMT2AMEN1CASP3SENP7
SCHEMBL7747808 0.85 RAB9A (0.64) SMN1; SMN2KMT2AMEN1CASP3SENP7
SCHEMBL19501838 0.84 MMP1 (0.86) SMN1; SMN2MMP1MMP2MMP9MAOA
SCHEMBL7746675 0.84 ALDH1A1 (0.53) HDAC1HDAC8HDAC6HCAR2HDAC3
SCHEMBL7746671 0.84 ALDH1A1 (0.53) HDAC1HDAC8HDAC6HCAR2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117881-A POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE ICOS CORPORATION (US) 2000-09-12 US disclosed