Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312284 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL6846585 | 0.73 | PTGS2 (0.44) | PTGS2PTGS1ALOX5APFEN1EPAS1 | |
| SCHEMBL6704623 | 0.69 | PTGS2 (0.39) | PTGS2PTGS1EPAS1 | |
| SCHEMBL6846488 | 0.66 | PTGS2 (0.36) | PTGS2PTGS1 | |
| SCHEMBL6739092 | 0.66 | NR3C1 (0.52) | PTGS2PTGS1 | |
| SCHEMBL6846588 | 0.65 | PTGS2 (0.39) | PTGS2PTGS1EPAS1 | |
| SCHEMBL6741612 | 0.63 | PTGS2 (0.45) | PTGS2PTGS1PDE3BPDE3A | |
| SCHEMBL5208053 | 0.62 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL5377415 | 0.62 | PTGS2 (0.40) | PTGS2PTGS1 | |
| SCHEMBL5831189 | 0.62 | KIF11 (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6020343-A | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors | MERCK FROSST CANADA, INC. (CA) | 2000-02-01 | — | — | US | disclosed |