Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203750 | 0.85 | GSTM2 (0.54) | SIRT5MAPTTDP1ATMKAT2B | |
| SCHEMBL8191816 | 0.82 | MAPT (0.61) | SIRT5MAPTLMNAHCAR3KAT2B | |
| SCHEMBL8194564 | 0.82 | ALDH1A1 (0.63) | SIRT5MAPTLMNAHCAR3KAT2B | |
| SCHEMBL17673300 | 0.81 | HPGD (0.57) | SIRT5MAPTTDP1MEN1KMT2A | |
| SCHEMBL1283854 | 0.81 | MAPT (0.54) | MAPTTDP1ATMLMNAL3MBTL1 | |
| SCHEMBL8200406 | 0.80 | ALDH1A1 (0.55) | SIRT5MAPTTDP1KMT2AATM | |
| SCHEMBL4359815 | 0.80 | MAPT (0.63) | SIRT5MAPTTDP1MEN1KMT2A | |
| SCHEMBL4695415 | 0.80 | HCAR3 (0.52) | SIRT5MAPTTDP1KMT2AHPGD | |
| SCHEMBL30697332 | 0.80 | HCAR3 (0.52) | SIRT5MAPTTDP1KMT2AHPGD | |
| SCHEMBL8191963 | 0.79 | MAPT (0.67) | SIRT5MAPTLMNAL3MBTL1KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096743-A | 1,2,3,4-tetrahydroquinoxalinedione derivative | YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| EP-0784054-A1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |