Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 8/20 | 0.38 |
| ▸ | RXRB | P28702 | 7/20 | 0.38 |
| ▸ | RXRG | P48443 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485862 | 0.84 | KDM4E (0.47) | HSD17B10ALOX15TSHRKDM4EHPGD | |
| SCHEMBL7485060 | 0.80 | SMN1; SMN2 (0.40) | TSHRKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL8196811 | 0.75 | KDM4E (0.35) | KDM4EALDH1A1 | |
| SCHEMBL1487907 | 0.71 | KDM4E (0.51) | HSD17B10ALOX15TSHRRXRAKDM4E | |
| SCHEMBL23090368 | 0.70 | DHODH (0.53) | HSD17B10ALOX15KDM4EHPGDALDH1A1 | |
| SCHEMBL818480 | 0.70 | ALDH1A1 (0.59) | HSD17B10ALOX15TSHRRXRARXRB | |
| SCHEMBL1814036 | 0.69 | LMNA (0.48) | TSHR | |
| SCHEMBL7797975 | 0.68 | KDM4E (0.51) | HSD17B10ALOX15KDM4EHPGDALDH1A1 | |
| SCHEMBL7485063 | 0.68 | PLA2G2A (0.33) | RXRARXRBRXRG | |
| SCHEMBL2273298 | 0.68 | ALDH1A1 (0.47) | TSHRKDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |