Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187493 | 0.87 | MAPT (0.50) | MAPTGAAPTGESALDH1A1MEN1 | |
| SCHEMBL8189588 | 0.83 | LMNA (0.43) | MAPTGAAPARP1ALDH1A1MEN1 | |
| SCHEMBL8196890 | 0.81 | PARP14 (0.42) | PARP1ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL4936663 | 0.78 | MAPT (0.51) | MAPTGAAPARP1ALDH1A1MEN1 | |
| SCHEMBL31716664 | 0.78 | TNKS2 (0.53) | MAPTPARP1ALDH1A1KMT2AGUSB | |
| SCHEMBL8200741 | 0.78 | TNKS2 (0.53) | MAPTPARP1ALDH1A1KMT2AGUSB | |
| SCHEMBL7428429 | 0.77 | PARP1 (0.54) | MAPTGAAPTGESPARP1ALDH1A1 | |
| SCHEMBL8190554 | 0.76 | KDM4E (0.40) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL8198084 | 0.76 | KDM4E (0.46) | MAPTPARP1ALDH1A1KMT2APOLB | |
| SCHEMBL8195380 | 0.75 | ALDH1A1 (0.39) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |