Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.60 |
| ▸ | TDP2 | O95551 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 4/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19954 | 0.91 | PGR (0.71) | PGRMEN1LMNAKMT2ATDP2 | |
| SCHEMBL22660 | 0.84 | AHR (0.61) | PGRTDP2GAAAHRGRIA1 | |
| Bromide SCHEMBL9824774 | 0.83 | AHR (0.59) | PGRTDP2GAAAHRGRIA1 | |
| Hydrochloric Acid SCHEMBL15206761 | 0.83 | AHR (0.59) | PGRTDP2GAAAHRGRIA1 | |
| SCHEMBL2993057 | 0.79 | TDP2 (0.67) | PGRMEN1LMNAMAPTRAB9A | |
| SCHEMBL516986 | 0.77 | KIF11 (0.67) | PGRMEN1LMNAKMT2ATDP2 | |
| SCHEMBL2616914 | 0.77 | TDP2 (0.73) | PGRMEN1LMNAMAPTRAB9A | |
| SCHEMBL3582558 | 0.76 | PGR (0.56) | PGRMEN1MAPTRAB9AKMT2A | |
| SCHEMBL3523425 | 0.76 | PGR (1.00) | PGRTDP2KIF11GRIA1CACNG8 | |
| SCHEMBL2374341 | 0.75 | MAPT (1.00) | PGRMEN1LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |