SCHEMBL2374341

SCHEMBL2374341

Nc1ccc2c(c1)Cc1cc([N+](=O)[O-])ccc1-2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 1.00
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
LMNA P02545 2/20 1.00
RAB9A P51151 2/20 1.00
TLR9 Q9NR96 2/20 1.00
TDP2 O95551 1/20 0.54
ALDH1A1 P00352 5/20 0.53
KDM4E B2RXH2 2/20 0.53
NPC1 O15118 1/20 0.53
HPGD P15428 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CRHBP P24387 1/20 0.50
CRHR2 Q13324 1/20 0.50
HSP90AA1 P07900 1/20 0.50
PGR P06401 2/20 0.49
PARP1 P09874 1/20 0.48
TDP1 Q9NUW8 3/20 0.46
CYP3A4 P08684 2/20 0.46
ALOX15 P16050 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Nitrofluorene SCHEMBL8006385 0.92 MAPT (0.85) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL14182815 0.92 RAB9A (0.85) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL7275458 0.90 MEN1 (0.81) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL30049268 0.89 TLR9 (0.79) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL987760 0.89 TLR9 (0.79) MAPTMEN1KMT2ALMNARAB9A
2-Nitrofluorene SCHEMBL644332 0.81 MAPT (0.68) MAPTMEN1KMT2ALMNARAB9A
2-Nitrofluorene SCHEMBL29450702 0.81 MAPT (0.68) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL5528874 0.79 TLR9 (0.66) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL5030144 0.79 TLR9 (0.66) MAPTMEN1KMT2ALMNARAB9A
SCHEMBL8927848 0.79 TLR9 (0.66) MAPTMEN1KMT2ALMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118004997-A Preparation method of pore-diameter-adjustable porous carbon material 东南大学 2024-05-10 CN claimed
US-9287568-B2 High performance, high durability non-precious metal fuel cell catalysts 3M INNOVATIVE PROPERTIES COMPANY (US) 2016-03-15 US claimed
CN-101657921-B High performance, high durability non-precious metal fuel cell catalysts 3M INNOVATIVE PROPERTIES CO US 2013-06-12 CN claimed
US-20110319257-A1 HIGH PERFORMANCE, HIGH DURABILITY NON-PRECIOUS METAL FUEL CELL CATALYSTS 3M INNOVATIVE PROPERTIES COMPANY 2011-12-29 US claimed
EP-2135313-B1 HIGH PERFORMANCE, HIGH DURABILITY NON-PRECIOUS METAL FUEL CELL CATALYSTS 3M INNOVATIVE PROPERTIES CO (US) 2011-09-14 EP claimed
CN-101657921-A High-performance, high durability non-precious metal fuel cell catalysts 3M INNOVATIVE PROPERTIES CO US 2010-02-24 CN claimed
EP-2135313-A1 HIGH PERFORMANCE, HIGH DURABILITY NON-PRECIOUS METAL FUEL CELL CATALYSTS 3M Innovative Properties Company (US) 2009-12-23 EP claimed
WO-2008127828-A1 HIGH PERFORMANCE, HIGH DURABILITY NON-PRECIOUS METAL FUEL CELL CATALYSTS 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-10-23 WO claimed
CN-118004997-A Preparation method of pore-diameter-adjustable porous carbon material 东南大学 2024-05-10 CN disclosed
US-9287568-B2 High performance, high durability non-precious metal fuel cell catalysts 3M INNOVATIVE PROPERTIES COMPANY (US) 2016-03-15 US disclosed
US-20140255386-A1 MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME NORTH CAROLINA STATE UNIVERSITY (US) 2014-09-11 US disclosed
CN-101657921-B High performance, high durability non-precious metal fuel cell catalysts 3M INNOVATIVE PROPERTIES CO US 2013-06-12 CN disclosed
WO-2013019469-A1 MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME THE WISTAR INSTITUTE (US) 2013-02-07 WO disclosed
US-20130023498-A1 MicroRNA Modulators and Method for Identifying and Using the Same The Wistar Institute and North Carolina State University 2013-01-24 US disclosed
WO-1996019458-A2 STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS LIGAND PHARMACEUTICALS INCORPORATED (US) 1996-06-27 WO disclosed
EP-0621962-A1 FUNCTIONALIZED MEROCYANINE DYES AND POLYMERS INCORPORATING SUCH DYES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-02 EP disclosed
US-5256784-A Merocyanine dyes MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-10-26 US disclosed
WO-1993015596-A2 FUNCTIONALIZED MEROCYANINE DYES AND POLYMERS INCORPORATING SUCH DYES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-08-05 WO disclosed
US-4153505-A PYROLYZED AROMATIC NITROGEN-CONTAINING THERMOSET FOAM MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1979-05-08 US disclosed
US-4128513-A BLACK, THERMOSET FOAM MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1978-12-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130023498-A1 MicroRNA Modulators and Method for Identifying and Using the Same AGO2, RNASE1, TRDMT1 MAPT 4079/4885MEN1 1708/4885KMT2A 1688/4885
US-20140255386-A1 MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME AGO2, RNASE1, TRDMT1 MAPT 4079/4885MEN1 1708/4885KMT2A 1688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.