Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30396121 | 0.87 | ULK1 (0.50) | KDM4ERAB9ANPC1GAAMEN1 | |
| SCHEMBL4045461 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1HPGDLMNARAB9A | |
| SCHEMBL18299060 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1HPGDLMNARAB9A | |
| SCHEMBL3620452 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1HPGDLMNARAB9A | |
| SCHEMBL29813095 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1HPGDLMNARAB9A | |
| SCHEMBL30396959 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1HPGDLMNAABCG2 | |
| SCHEMBL703198 | 0.82 | KDM4E (0.58) | KDM4EALDH1A1HPGDLMNARAB9A | |
| SCHEMBL6704950 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1HPGDLMNARAB9A | |
| SCHEMBL8200409 | 0.78 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDLMNARAB9A | |
| SCHEMBL699482 | 0.76 | FLT3 (0.60) | KDM4EALDH1A1HPGDLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071522-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS METHIONYL T-RNA SYNTHETASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-30 | — | — | WO | disclosed |