Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195937 | 0.86 | MAPT (0.41) | MAPTKMT2APARP1CNR2LTC4S | |
| SCHEMBL1513035 | 0.85 | GLA (0.44) | LMNAMAPTKMT2ACNR2GAA | |
| SCHEMBL6220889 | 0.82 | GRM5 (0.50) | KMT2APARP1ALOX15GRM5ALDH1A1 | |
| SCHEMBL8196200 | 0.81 | MAPT (0.40) | LMNAMAPTKMT2ASMN1; SMN2GRM5 | |
| SCHEMBL8194190 | 0.79 | ALDH1A1 (0.49) | MAPTPARP1ALOX15GRM5ALDH1A1 | |
| SCHEMBL15647834 | 0.77 | GRM5 (0.52) | LMNAMAPTKMT2ASMN1; SMN2GRM5 | |
| SCHEMBL8198559 | 0.77 | CYP3A4 (0.44) | PARP1ALOX15CYP3A4CYP2C19PDE4B | |
| SCHEMBL16632079 | 0.75 | VNN1 (0.48) | LMNAMAPTKMT2ASMN1; SMN2PARP1 | |
| SCHEMBL165279 | 0.75 | KEAP1 (0.46) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30489829 | 0.75 | SMO (0.39) | LMNAGAAPDE4BPDE4DFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |