Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14521552 | 0.80 | KMT2A (0.60) | NPC1ALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL6164740 | 0.78 | ALPL (0.55) | NPC1KMT2AMEN1TDP1USP2 | |
| SCHEMBL14277889 | 0.75 | POLB (0.64) | NPC1KMT2AMEN1TDP1USP2 | |
| SCHEMBL7504253 | 0.75 | POLB (0.64) | NPC1KMT2AMEN1TDP1USP2 | |
| SCHEMBL7499733 | 0.71 | ALDH1A1 (0.62) | NPC1ALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL6166102 | 0.69 | NPC1 (0.52) | NPC1KMT2AMEN1TDP1USP2 | |
| SCHEMBL5387895 | 0.68 | ALDH1A1 (0.50) | NPC1ALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL5395538 | 0.68 | ALDH1A1 (0.50) | NPC1ALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL660720 | 0.68 | KDM4C (0.47) | NPC1ALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL8517299 | 0.68 | USP2 (0.56) | NPC1KMT2AMEN1TDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |