Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glucuronate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TOP2A | P11388 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 2/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mercaptopurine Anhydrous SCHEMBL905281 | 0.81 | HTT (0.37) | LMNAHTTTSHRPI4KAPI4K2B | |
| Mercaptopurine Anhydrous SCHEMBL4456159 | 0.80 | HTT (0.38) | LMNAHTTTSHRPI4KAPI4K2B | |
| Ribose (Furanose) SCHEMBL831005 | 0.79 | CYP3A4 (0.39) | LMNAHTTTSHRPI4KAPI4K2B | |
| Ribose (Furanose) SCHEMBL7680729 | 0.79 | CYP3A4 (0.39) | LMNAHTTTSHRPI4KAPI4K2B | |
| Mercaptopurine Anhydrous SCHEMBL29684795 | 0.73 | LMNA (0.57) | LMNAHTTPI4KAPI4K2BPI4K2A | |
| Mercaptopurine Anhydrous SCHEMBL8844 | 0.73 | LMNA (0.57) | LMNAHTTPI4KAPI4K2BPI4K2A | |
| Mercaptopurine Anhydrous SCHEMBL734088 | 0.72 | LMNA (0.55) | LMNAHTTPI4KAPI4K2BPI4K2A | |
| Mercaptopurine Anhydrous SCHEMBL30834915 | 0.72 | LMNA (0.55) | LMNAHTTPI4KAPI4K2BPI4K2A | |
| Mercaptopurine Anhydrous SCHEMBL31379732 | 0.72 | LMNA (0.55) | LMNAHTTPI4KAPI4K2BPI4K2A | |
| Mercaptopurine Anhydrous SCHEMBL5144254 | 0.72 | LMNA (0.55) | LMNAHTTPI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6146658-A | ADMINISTERING A GLYCOSYL-SPACER-DRUG COMPOUND WHERE THE GLYCOSYL IS A SACCHARIDE WHICH CAN BE ENZYMATICALLY CLEAVED; DRUG IS ANTIINFLAMMATORY, IMMUNOSUPPRESSIVE OR ANTITUMOR AGENT WHICH HYDROXYL OR AMINO GROUP; SELF-ELIMINATING SPACER | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-11-14 | — | — | US | disclosed |
| US-5955100-A | TREATMENT OF MALIGNANT TUMORS, INFLAMMATORY DISEASES, OR AUTOIMMUNE DISEASES | BEHRINGWERKE AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | disclosed |