Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.71 |
| ▸ | DRD1 | P21728 | 2/20 | 0.71 |
| ▸ | DRD4 | P21917 | 1/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.68 |
| ▸ | BCHE | P06276 | 1/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29748937 | 0.88 | LMNA (0.81) | DRD2DRD1BCHELMNAKDM4E | |
| SCHEMBL29924522 | 0.88 | LMNA (0.81) | DRD2DRD1BCHELMNAKDM4E | |
| SCHEMBL2112478 | 0.88 | LMNA (0.81) | DRD2DRD1BCHELMNAKDM4E | |
| SCHEMBL29837028 | 0.88 | LMNA (0.81) | DRD2DRD1BCHELMNAKDM4E | |
| Hydrochloric Acid SCHEMBL14691397 | 0.87 | LMNA (0.79) | DRD2DRD1BCHELMNAKDM4E | |
| SCHEMBL29052976 | 0.84 | DRD2 (0.89) | DRD2DRD1DRD4BCHEACHE | |
| SCHEMBL18179207 | 0.84 | DRD2 (0.89) | DRD2DRD1DRD4BCHEACHE | |
| SCHEMBL10108786 | 0.84 | TBXA2R (0.61) | DRD2DRD1DRD4TBXA2RBCHE | |
| SCHEMBL29641507 | 0.84 | DRD2 (0.80) | DRD2DRD1DRD4BCHEACHE | |
| SCHEMBL29373104 | 0.84 | DRD2 (0.89) | DRD2DRD1DRD4BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008097546-A2 | COMPOUNDS THAT INHIBIT CHOLINESTERASE | COLUCID PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |