Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 4/20 | 0.53 |
| ▸ | NT5E | P21589 | 1/20 | 0.53 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | PNP | P00491 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | KRAS | P01116 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535718 | 0.87 | HINT1 (0.58) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL2424287 | 0.86 | HINT1 (0.55) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL7541561 | 0.86 | TAAR1 (0.56) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL7111072 | 0.84 | HINT1 (0.55) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL23710671 | 0.84 | TAAR1 (0.58) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL23200376 | 0.84 | TAAR1 (0.58) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL23200375 | 0.84 | TAAR1 (0.58) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL800400 | 0.84 | TAAR1 (0.58) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL23710670 | 0.84 | TAAR1 (0.58) | HINT1NT5ESTING1PDE3BPDE3A | |
| SCHEMBL780400 | 0.84 | TAAR1 (0.58) | HINT1NT5ESTING1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934325-A4 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | PHARMASSET LTD (US) | 2000-08-16 | — | — | EP | claimed |
| EP-0934325-A1 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | Pharmasset, Ltd. (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1998015563-A1 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | PHARMASSET, LTD. (US) | 1998-04-16 | — | — | WO | claimed |