Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 6/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198980 | 0.87 | HTR2C (0.55) | HTR2CHTR7SLC18A3DRD2CHRM2 | |
| SCHEMBL8199080 | 0.87 | CYP26A1 (0.49) | CYP26A1HTR2CHTR7SLC18A3DRD2 | |
| SCHEMBL8204421 | 0.85 | HTR2C (0.48) | CYP26A1HTR2CHTR7SLC18A3DRD2 | |
| SCHEMBL8201012 | 0.85 | HTR2C (0.53) | HTR2CHTR7SLC18A3DRD2CHRM2 | |
| SCHEMBL8199275 | 0.85 | SIGMAR1 (0.50) | HTR2CHTR7DRD2CHRM2CHRM4 | |
| SCHEMBL8199521 | 0.84 | DRD2 (0.58) | CYP26A1CYP19A1HTR2CHTR7DRD2 | |
| SCHEMBL8190999 | 0.84 | HTR7 (0.52) | CYP26A1HTR2CHTR7DRD2CHRM2 | |
| SCHEMBL8198852 | 0.84 | ADRA1D (0.57) | CYP26A1HTR2CHTR7DRD2SIGMAR1 | |
| SCHEMBL8200365 | 0.83 | HTR2C (0.51) | HTR2CHTR7DRD2SIGMAR1 | |
| SCHEMBL8200489 | 0.83 | CYP24A1 (0.48) | CYP26A1HTR2CHTR7DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |