Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202309 | 0.92 | HTR2C (0.43) | HTR2CDRD2HTR1DHTR1BOPRM1 | |
| SCHEMBL8199804 | 0.89 | HTR2C (0.49) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8202320 | 0.85 | USP5 (0.52) | HTR2CDRD2MCHR1 | |
| SCHEMBL8588802 | 0.83 | HTR2C (0.48) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8202304 | 0.83 | HTR2C (0.47) | HTR2CDRD2MCHR1 | |
| SCHEMBL8198570 | 0.83 | HTR2C (0.47) | HTR2CDRD2OPRM1OPRK1HTR2A | |
| SCHEMBL8199074 | 0.82 | HTR2C (0.48) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8204772 | 0.82 | HTR2C (0.50) | HTR2CDRD2MCHR1 | |
| SCHEMBL8200236 | 0.82 | DRD2 (0.40) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8199695 | 0.82 | SLC6A2 (0.46) | HTR2CDRD2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |